ea0022p283 | Diabetes | ECE2010
Katalinic Darko
, Nikolac Nora
, Zjacic-Rotkvic Vanja
, Topic Elizabeta
, Solter Miljenko
, Plestina Stjepko
Background: Type 2 diabetes (T2D), which is multifactorial, inherited and progressive chronic disorder, is characterised by hyperglycemia due to defects in insulin secretion and action. The sulfonylurea receptor (SUR1) and the insulin receptor (INSR) are critical elements in insulin-signalling pathways, and mutations in the SUR1 and INSR genes have been reported to have a role in determining susceptibility to T2D.The aim was to study whether the -3 C/T p...